To predict the risk of having colorectal adenoma and colorectal cancer: ≥45 years old. The American Cancer Society (ACS) recommends that adults aged 45 years or above with an average risk of colorectal cancer undergo regular screening. In certain high-risk individuals, including those with a family history of colorectal cancer, any inherited mutations, or other known risk factors, screening is recommended to begin at an earlier age. For stool-based tests, the ACS recommends regular screening every 1-3 years. For more information, please consult your doctor.
For regular monitoring of gut microbial health: Any age M3CRC can inform you of exposure to a hostile microbial environment that can promote colorectal cancer. Anyone can take the test to stay informed about his or her colorectal cancer-related gut microbial health. Please consult your doctor if you are interested in the test.
Q2. How does the microbiome relate to colorectal adenoma and colorectal cancer?
Experiments show that the gut microbiota is involved in colorectal cancer formation and progression. Clinically, patients with colorectal adenoma and colorectal cancer also have a characteristic “CRC microbiome” that is different from the microbiome of healthy people. Certain microbes within the microbiome can secrete toxins, damage DNA, and stimulate inflammation, contributing to adenoma and cancer
Q3. How can I improve my gut microbiome?
Lifestyle modifications can improve the human gut microbiome. Evidence suggests dietary intervention, weight reduction, and the administration of probiotics, prebiotics, or synbiotics can modulate the gut microbiome. The M3CRC contains a dietary recommendation that is tailored to test results.
Q4. What are the scientific evidence behind the test?
The test is based on a clinical study involving over 1,000 colorectal adenoma, colorectal cancer, and control subjects. The test score is significantly elevated in patients with colorectal adenoma and colorectal cancer patients compared with control subjects (p<0.0001)
Q5. What is the value proposition of M3CRC risk prediction test?
M3CRC risk prediction test is more sensitive than other commercially available tests at detecting colorectal adenoma and colorectal cancer. At 85% specificity, M3CRC has sensitivities of 40% for non-advanced adenoma 45% for advanced adenoma, and 94% for colorectal cancer. This is respectively a 30%, 20%, and 20% increase in accuracy compared to FIT, a widely used risk prediction test.
Q6. Does the M3CRC risk prediction test complement with endoscopy?
Yes. M3CRC can serve as a non-invasive and early step to identify patients who are at higher risk of colorectal adenoma and colorectal cancer, who are otherwise reluctant to perform endoscopy.
Q7. How often should I prescribe M3CRC risk prediction test to my patients?
Based on re-screening practices in Hong Kong and advices of US Centers for Disease Control and Prevention, G-NiiB recommends a follow-up test every year
Q8. Can I take the test if I have been on antibiotics?
We recommend a wait of at least one month after any short-term antibiotic use before testing.
Again, this is because it is best to sample at a time that reflects your “normal” gut microbiome
Q9. Can I take the test when I am sick or suffer from long-term health conditions?
Yes, anyone can take our test. Our method of examining your gut bacteria is non-invasive and the initial test can be completed at your home. If you have a medical condition, please consult with a medical professional before making any changes to your diet or lifestyle.
Q10. Will medicines interfere with my results?
Yes. Some medications can change your gut microbiome. However, it is not necessary to stop with long-term medications before taking the test, if these medications are part of your normal diet.
If in doubt, consult our customer support.
